Dinuclear zinc(II) complexes containing (benzimidazol-2-yl)benzene that overcome drug resistance in hepatocellular carcinoma cells through induction of mitochondria fragmentation.

نویسندگان

  • Qiang Xie
  • Shenggui Liu
  • Xiaoling Li
  • Qiong Wu
  • Zuandi Luo
  • Xiaoyan Fu
  • Wenqiang Cao
  • Guoqiang Lan
  • Dan Li
  • Wenjie Zheng
  • Tianfeng Chen
چکیده

Herein we demonstrated that dinuclear zinc complexes could overcome drug resistance in R-HepG2 drug resistance hepatocellular carcinoma cells through induction of mitochondria-mediated apoptosis or by triggering mitochondria fragmentation, depletion of the membrane potential and intracellular ATP levels.

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عنوان ژورنال:
  • Dalton transactions

دوره 43 19  شماره 

صفحات  -

تاریخ انتشار 2014